UJI AKTIVITAS ANTIBAKTERI GEL EKSTRAK DAUN PETAI  (Parkia SpeciosaHassk.) TERHADAP BAKTERI STAPHYLOCOCCUSAUREUS

Rahma Nafi’ah; Etty Haryati; Neneng Cahya Tamara

doi:10.51873/jhhs.v1i2.16

Authors

Rahma Nafi’ah Sekolah Tinggi Farmasi YPIB Cirebon
Etty Haryati Sekolah Tinggi Farmasi YPIB Cirebon
Neneng Cahya Tamara Sekolah Tinggi Farmasi YPIB Cirebon

DOI:

https://doi.org/10.51873/jhhs.v1i2.16

Keywords:

Minimum Inhibitory Concentration (MIC), Parkia speciosa leaf (Parkia speciosa Hassk.), Staphylococcus aureus

Abstract

Background: Petai leaf (Parkia Speciosa Hassk) contains flavonoids and terpenoids that are suspected of having antibacterial activity. KHM values ??were tested at 2.5% extract concentration, 5.0% and 7.5%. From the results of KHM values ??obtained then developed formulations using gel base HPMC, Karbopol and Gom Arab.

Objective: To find out the value of KHM from petai leaf extract (Parkia Speciosa Hassk) and gel base which has the best and stable antibacterial activity value to storage condition.

Methods: This research method using a kind of experimental research. The test results were analyzed using a statistical calculation method Analysis Of variance (ANOVA) one line and then proceed with the t-test method.

Result: The results showed that parkia speciosa leaf extract contains compounds terpenoid and flavonoid, and have antibacterial activity, MIC parkia speciosa leaf extract 2,5%, all gel formulation has antibacterial activity. The carbopol base gel has the most excellent antibacterial activity. All gel formulation is stable at a temperature of 25^oC, less stable at a temperature of 0^oC and 40^oC .

Conclusion: At 2.5% concentration, petai leaf extract already has antibacterial activity against Staphylococcus aureus bacteria.